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(1) Brodzinsky R, Singh HB; Volatile Organic Chemicals in the Atmos SRI International Contract (1982) (2) Arnts RR, Meeks SA; Atmos Environ 15: 1643-51 (1981 peer reviewed* urban/suburban: Acetone was detected at a concn of 1-8 ppb in Denver, CO(1).Under normal conditions, the production of ketone bodies occurs almost entirely within the liver and to a smaller extent in the lung and kidney.Produced extensive tubular and centrilobular necrosis when administered to ketone-pretreated rats.10*QC reviewed* Biological Exposure Index (BEI Determinant: acetone in urine; Sampling Time: end of shift; BEI: 50 mg/l.The methylglyoxal pathway is responsible for the conversion to acetol, acetol to methylglyoxal, subsequent conversion of methylglyoxal to glucose.The general population may be exposed to acetone through the use of commercially available products containing this compound such as paints, adhesives, cosmetics, and rubber cements.Acetone was detected at a concn of 10 and less than 1 ng/l in 2 elementary school classrooms in France(4).IN humans IS rapid FOR 8 HR afteingle oral dose BUT WAS NOT complete IN.American Conference of Governmental Industrial Hygienists TLVs and BEIs.90*QC reviewed* niosh Recommendations: Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 250 ppm (590 mg/cu m).In crime of prostitution occurs when case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes.
Vapor-phase acetone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC the half-life for this reaction in air is estimated to be about 71(3,SRC) days.




Exponential phase cultures of the yeast were treated with nocodazole, ethyl acetate, acetone, and methyl ethyl ketone alone or in combination, incubated at 28 degrees C for 4 hours, held in an ice bath for 16 hours, incubated at 28 degrees C for an additional.New York, NY: Van Nostrand Reinhold., 1983.,.Do not handle broken packages without protective equipment.Monsanto, chevron, shell AND cyanamid have closed approximately 445 million LB OF acetone capacity since 1982 chemical profile: acetone, (1985 peer reviewed* during 1984, approximately 15 OF US acetone output WAS derived from isopropanol chemical products synopsis: acetone, 1984*peer reviewed*.40-0.45 kg of acetone per.3-284*peer reviewed* Color/Form: Colorless liquid Lewis,.J., Sr (Ed.).Sato A, Nakajima T; Scand J Work Environ Health 13: 81-93 (1987 peer reviewed* Henry's Law constant.87X10-5 atm-cu m/mole at 25 deg C Benkelbberg HJ et al; J Atmos Chem 20: 17-34 (1995 peer reviewed* Chemical Safety Handling: DOT Emergency Guidelines: Fire or explosion.1(78) 186*peer reviewed* Acetone can be placed among solvents of comparatively low acute and chronic toxicities.Environmental Contaminant Reference Databook Volume.Breathing higher levels of contaminated air in the workplace or from using products that contain acetone (for example, household chemicals, nail polish, and paint).
187*peer reviewed* Environmental Fate Exposure: Environmental Fate/Exposure Summary: Acetone's production and use as a solvent for fats, oils, waxes, resins, rubbers, plastics, pharmaceuticals and rubber cements may result in its release to the environment through various waste streams.
4-9 (1990) (4) Benkelbberg HJ et al; J Atmos Chem 20: 17-34 (1995) (5) Rathbun RE et al; J Hydrol 104: 181-209 (1988) (6) Rathbun RE et al; J Hydrol 123: 225-42 (1991) (7) Rathbun RE et al; Environ Pollut 79: 153-62 (1993) (8) Franke.

325-10*QC reviewed* Flammability:.
Centrilobular necrosis produced by n-nitrosodimethylamine was more severe after pretreatment with inducers.
Pupils dilated or normal.


[L_RANDNUM-10-999]

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